Childhood Cancer: Research Progress and Future Prospects

In recent years, the incidence of childhood cancer has been increasing, but children suffering from cancer have not received enough attention from all walks of life. How to make breakthroughs in the field of childhood cancer treatment and find more accurate and effective treatments is a problem that scientists worldwide have been exploring. Recent research on childhood cancer has made some new progress.

Precision medicine of childhood cancer: JAMA Network Open published a research result of the CHU Sainte-Justine TRICEPS team that genomic profiling will help clinical treatment of childhood cancer. Until April 2019, the team had enrolled 84 patients. In 87% of patients, the study identified genomic anomalies that allowed for better patient management. The therapeutic alternatives are personalized because the proposed actions will be different for each patient. The discoveries can lead to a “targeted” therapy because it specifically seeks to block (or bypass) the action of genes that cause cancer progression.

Gene technology for Ewing sarcoma: Ewing sarcoma is a childhood cancer driven by EWS-ETS transcription factor fusion oncoproteins. The majority of tumors express wild-type TP53, and thus, therapies targeting the p53 pathway would benefit most patients. To discover targets specific for TP53 wild-type Ewing sarcoma, scientists used a genome-scale CRISPR-Cas9 screening approach and identified and validated MDM2, MDM4, USP7, and PPM1D as druggable dependencies.

New target for treating childhood cancer: SWI/SNF is a multi-component protein complex that plays an important role in chromatin remodeling. It is also likely an important tumor suppressor, as indicated by the fact that approximately 20% of human cancers carry a mutation in one or more SWI/SNF protein components. This SWI/SNF component protein is mutated in a number of cancers, including malignant rhabdoid tumor (MRT), a highly aggressive, nearly uniformly fatal childhood cancer. William Tansey and his laboratory found that cancers bearing an SNF5 mutation may be susceptible to therapy by MYC inhibition, providing yet another reason why the discovery of clinically viable MYC inhibitors is of utmost importance.

The purpose of modern childhood cancer treatment is not only for the survival rate and the extension of survival time, but also to improve the quality of life. The principle of treatment of pediatric tumors has been raised to the integration of eradication of tumor, functional maintenance and mental health.

For the first two principles, childhood cancer patients are very different from adults, for they are at the stage of growth, thus the treatment plan must take the impact of treatment on the normal development of children into consideration. For example, the widespread use of radiation therapy in adults has been severely limited in childhood cancer treatment due to the risk of skeletal deformities, gonad damage, and intellectual effects in children. In the future, there will be anti-tumor drugs and treatment being more safe, effective, and less toxic, such as biological treatment, gene therapy, differentiation induction therapy to replace traditional chemotherapy and radiotherapy.

For mental health, on the basis of further improvement of tumor eradication and long-term survival, the mental health of children with tumors will be increasingly valued. Psychological problems, including children’s self-experience, psychological effects, concerns about relapses and difficulties in participating in society, should be brought to the attention. Parents should be noticed that organ function and appearance reconstruction are also necessary for those who have suffered growth stagnation, and whose appearance is abnormal due to surgery and radiation therapy.

How To Cure Weak Erection, Natural Treatments And Remedies?

Weak erection is the inability to obtain and maintain an erection for satisfactory lovemaking. Weak erection involves improper functioning of male reproductive organ consequently the male organ is unable to get or maintain erection during lovemaking act.

There may be several causes of erectile dysfunction leading to male impotency. These causes may be physical as well as psychological such as stress, depression, anxiety etc. Some other causes include deficiency of potassium, hormonal insufficiency, cardiac diseases, diabetes and psychological factors. Erectile dysfunction can also occur as a result of side effect of any drug like anti depressant.

The problem erectile dysfunction or erectile dysfunction should be treated well in time otherwise it may lead to many problems in your life such as tension, lack of concentration in work, relationship problems, etc. For solving this problem it is necessary to know that how to cure erectile dysfunction. There are many treatments and remedies to cure weak erection and ED problem. One thing should be remembered that you should opt for only herbal and natural treatments to cure ED out of all available alternatives, because natural remedies to cure weak erection have less risk of side effects.

Today, the best natural treatment to cure weak erection is Bluze capsules. Bluze capsule is a natural product that is very effective and powerful to cure ED without any side effect. Bluze capsules are made of natural and herbal ingredients such as kaunch (mucuna pruriens bek), jaiphal (myristica fragrans), ghokaru (pedalium murex), shilajit (asphaltum puniabiunum), shatavari (asparagus racemosus), moti (pinctada maragaritifera), semar (bambax malabaricum), kesar (crocus sativus or saffron), ashwagandha (withania somnifera), safed musli (asparagus adscendens), vidarikand (pueraria tuberosa dc), tambul (piper betle linn), salabmisri (orchis mascula/eulophia), talmakhana (hygrophila spinosa), kharethi (sida cordifolia), akarkara (anacyclus pyrethrum), dalchini (cinnamomum zeylanicum), kuchala (strychnos nux-vomica linn), jaipatri (myristica fragrans), tulsi (ocimum sanctum linn).

You should regularly take Bluze capsules with water or milk twice a day for three to four months, for getting complete relief from weak erection or erectile dysfunction problem.

Along with use of Bluze capsules, you may also try some of the other natural remedies to cure ED problem. You should increase the intake of zinc and vitamins in your diet and you should reduce the intake of junk food. It will work as a good treatment to cure weak erection. You should regularly practice some exercises also to cure this problem. As side effects of some prescribed medicine like anti-depressants, medicines for high blood pressure, antiulcer drugs may also cause ED you should talk with your doctor before taking this medicines to prevent yourself from this type of problems. You should also take a sufficient rest and sleep of at least 8 to 9 hour per day. All these remedies will help you to cure ED problem.

Along with the use of all these natural treatments to cure weak erection, you should regularly take Bluze capsules with water or milk twice a day for three to four months, for getting complete relief from ED problem naturally.

History and Development of Black Steel Pipe

History of black steel pipe

William Murdock made the breakthrough leading to the modern process of pipe welding. In 1815 he invented a coal burning lamp system and wanted to make it available to all of London. Using barrels from discarded muskets he formed a continuous pipe delivering the coal gas to the lamps. In 1824 James Russell patented a method for making metal tubes that was fast and inexpensive. He joined the ends of flat iron pieces together to make a tube then welded the joints with heat. In 1825 Comelius Whitehouse developed the “butt-weld” process, the basis for modern mild steel pipe making.

Developments of black steel pipe

Whitehouse’s method was improved upon in 1911 by John Moon. His technique allowed manufacturers to create continuous streams of pipe. He built machinery that employed his technique and many manufacturing plants adopted it. Then the need arose for seamless structural steel pipes. Seamless pipe was initially formed by drilling a hole through the center of a cylinder. However, it was difficult to drill holes with the precision needed to ensure uniformity in wall thickness. An 1888 improvement allowed for greater efficiency by casting the billet around a fire-proof brick core. After cooling, the brick was removed, leaving a hole in the middle.